Kolagen - molekile nini na nto

Kolagen irashobora kugabanywamo: molekile nini ya kolagen hamwe na molekile ntoya ya kolagen peptide.
Amenyo mu biryo dusanzwe turya arimo molekile nini za poroteyine zifite uburemere bwa dalitoni 300.000 cyangwa zirenga, zidahita zinjira nyuma yo kurya, ariko zikavamo aside amine muri sisitemu y'ibiryo, zigategereza ko zongera gutunganywa, kandi ntibizwi niba amaherezo bagize collagen, ifite igipimo gito cyo kwinjiza.

Abantu bagenzuye kolagen ifite uburemere bwa molekile igera kuri 6000 hakoreshejwe aside-base hamwe na tekinike ya enzymatique kandi bayita peptide ya kolagen. Peptide ni ikintu kiri hagati ya aside amine na proteyine za macromolecular. Acide ebyiri cyangwa nyinshi za aminide zifite umwuma kandi zegeranye kugira ngo zibe peptide nyinshi kugirango zibe peptide, kandi peptide nyinshi zizingiwe mu nzego nyinshi kugirango zibe molekile ya poroteyine. Peptide ni ibice bya poroteyine byuzuye hamwe na molekile zingana na nanometero, byoroshye kwinjizwa mu gifu, amara, imiyoboro y'amaraso ndetse n'uruhu, kandi igipimo cyacyo cyo hejuru kiri hejuru cyane ya poroteyine nini za molekile.

Peptide ya kolagen ifite uburemere bwa daltons 6000 cyangwa munsi yayo igabanijwemo peptide ifite uburemere bwa molekile ya 1000-6000 na peptide ifite uburemere bwa molekile ya daltoni 1000 cyangwa munsi yayo. Mubisanzwe, umubare wa aside amine muri oligopeptide ni kuva kuri bibiri kugeza cyenda. Ukurikije umubare wa acide amine muri peptide, hariho amazina atandukanye: ikomatanyirizo ryakozwe na dehidrasique ya molekile ebyiri za aside amine yitwa dipeptide, kandi nikigereranyo kimwe, hariho tripeptide, tetrapeptide, pentapeptide, nibindi, kugeza icyenda. peptide; mubisanzwe ifumbire ikozwe na dehidration ya kanseri ya molekile 10-50 yitwa polypeptide.
Mu myaka ya za 1960, byagaragaye ko oligopeptide ishobora kwinjizwa idafite gastrointestinal, ishobora kugabanya cyane umutwaro wa gastrointestinal na umwijima no kunoza bioavailable; kandi irashobora kugira uruhare rutaziguye muri synthesis ya kolagen yabantu itavunitse muri aside amine, mugihe peptide idashobora kubigeraho.
Kubwibyo, ugomba kwitondera uburemere bwa molekuline ya peptide ya kolagen mugihe uyiguze.